Some people find they sleep better during fasts, while others struggle with hunger keeping them awake. If you feel lightheaded or unusually fatigued, it’s often a sign that you need more electrolytes, not more food. A small amount of bone broth can provide both hydration and electrolytes without breaking your fast. At the 36-hour mark, your body has been in a fasted state long enough to trigger some serious adaptations.
Intermittent Fasting 20/4: Results, Side Effects, and How to
“Extended fasting periods, like the 36-hour fast, can enhance brain health by stimulating the production of brain-derived neurotrophic factor (BDNF), which supports neuron growth and protection.” If you struggle with a 24-hour fast, try first skipping certain meals or eating only during an eight-hour period. Less restrictive fasts are a good starting point if you’re new to fasting. During the first day of fasting, your body taps into its carbohydrate stores. It uses these stores (glycogen stores) as fuel for your body and brain.
- For some people, extended fasting can trigger unhealthy thoughts about food or lead to binge eating afterward.
- What is important to note is that fasting is defined as short-term or long-term abstinence from food (primary), and can last from 8 hours to several weeks.
- Whole-day fasting trials lasting 12 to 24 weeks also favorably improve blood lipids (5%–20% reduction in total cholesterol and 17%–50% reduction in triglycerides) [8].
- Sleep quality can be affected, particularly if you’re used to having a late-night snack.
- Thus, the main aim of this study was to estimate the effect of a 48 h, zero-calorie diet with water provided ad libitum on autonomic function, brain activity, cognition, and mood in amateur weight lifters.
- We see glucagon is released to balance the blood sugar out, and we do around 13 hours start to see some autophagy.
The 5 Stages of Fasting (And The Benefits of Each One)
Some individuals report improved clarity of vision and a heightened perception of colors during prolonged fasts. Extended fasts have been found to lower levels of inflammation in the body. Betts said his own research, in which people do not eat from Monday to Friday, suggested it could take several days for cognitive benefits to be felt. But a lot of the research hasn’t really [been borne out in] human beings. So we don’t see dramatic health benefits, certainly in the short term,” he said. Anti-inflammatory and neuroprotective benefits of IF and CR have been reported in animal models of stroke [90] and systemic infections as well as in humans with inflammatory systemic conditions [41].
1. The Effect of Short-Term Fasting on Human Psychological Health
Growth hormone levels may also increase, promoting muscle growth and fat loss. Fasting impacts appetite and metabolism hormones related to appetite (ghrelin and leptin), which reduces hunger and decreases food intake, boosting weight loss. During fasting, when glucose and glycogen are used up, the body starts to use fatty acids and ketones to produce the necessary energy for the body, which triggers autophagy to optimize energy use and ensure cellular survival.
In opposition, glucagon increases, promoting the production of glucose and ketones in the liver. However, fasting for 36 to 72 hours typically leads to a noticeable drop in body weight, with some individuals reporting weight loss of up to 2 to 5 pounds. While both strategies promote metabolic health, intermittent fasting is commonly used for long-term maintenance, helping to stimulate fat metabolism and support weight management.
What Happens to Your Body When You Fast
While you might be most interested in only fat burn, metabolic flexibility — the ability and ease that your body has to choose to burn either fats or carbohydrates — is important and a key indicator of metabolic health. Your meal’s protein will be fully digested anywhere between 30 minutes to 4 hours, depending on the type of proteins you just ate. Fats, another main fuel source for the body, are mostly broken down in the small intestine to their simpler chemical building block, triglycerides. Some triglycerides circulate throughout the bloodstream, providing energy to your cells and brain, while most others are stored for future energy use. Most doctors and nutritionists agree that there are five stages of fasting. The clock starts from Hour 0 (your last bite of food) and ends… whenever you choose to.
This metabolic adaptation is a survival mechanism, allowing the body to conserve protein stores by reducing the need for gluconeogenesis. The use of ketones contributes to a stable energy supply, which many people report as increased mental clarity and reduced hunger. A 2023 study of 209 people found intermittent fasting 3 days per week can reduce the risk of type 2 diabetes by increasing insulin sensitivity. As you move beyond the 4-hour mark and continue up to 16 hours of fasting, your body enters a state called glycogenolysis.
4 vs Other Intermittent Fasting Methods

I was hesitant to try for this length of time, having only completed one 24-hour fast last month. To ensure I get some electrolytes when fasting I put a few pinches of Himalayan rock salt into 600ml of warm water a couple of times per day. There is no need to go for any supplements or rehydrating electrolyte sachets here, this is a cheaper and easier solution. One important point about fasting is to ensure you drink plenty of fluids to avoid dehydration. Be aware that if you drink a lot of black tea and coffee, you may need to drink even more water to compensate for their diuretic effects. There can be side effects, some can be serious depending on your health.
How to Do the 36 Hour Fast in a Healthy Way?
Brain, heart and skeletal muscle accumulate high levels of oxidative damage, and these organs are therefore targets for several age-related disorders that are attenuated by CR [97,98]. For healthy people, fasting improves systemic metabolic indices and enhances the functions of multiple organs, thereby creating a beneficial cycle, especially in young adults [99–101]. In older adults with mild cognitive impairment, a 36-month IF regimen may reduce the level of oxidative stress by increasing superoxide dismutase activities [102,103]. Available studies provide overwhelming evidence that IF is a safe and promising approach to prevent chronic diseases, maintain a healthy weight, and improve metabolic health. IF regimes have been reported to lower fasting insulin concentrations [31–33], and HbA1c (glycated hemoglobin) [34–37] in otherwise healthy individuals with obesity and/or prediabetes.
Insulin levels are at their lowest point, which means your body is incredibly efficient at burning fat for fuel. We’re now planning to look at how much of this is due to losing weight vs. fasting duration. Think about what you want to achieve with your intermittent fasting schedule before you choose the best plan for you. Some people can take time away from food without too much stress; others become very uncomfortable if they go without eating for too long.
What are the top benefits of prolonged fasting?
However, we always remind our listeners to consult a doctor before embarking on any extended fasts, as they can be physically and mentally demanding. To flush out water weight, you may need to implement some changes in your diet. You may need to increase your consumption of potassium, reduce simple carbs, reduce sodium, and drink plenty of water. In addition, you need to increase the amount of physical exercise you do.
Metabolic Adaptation
Whether you’re just starting with intermittent fasting or are interested in a prolonged 5-day fast, let’s jump into the science of what happens to your body during the stages of fasting, hour by hour. When you first start an intermittent fasting schedule, yes, you’re going to be hungry. Your body is used to eating at regular intervals and changing that schedule can impact your hunger cues. Some people report feeling less hungry over time as the body adapts, though this can vary from person to person. If you are considering weight loss or seeking certain health benefits, you can try a 60-hour fast, but you need to remember that sustainable weight loss is not an overnight act. You must have a balanced diet accompanied by regular exercise to have a healthy body.
72 Hours: Insulin Sensitivity and Increased Fat Loss
Be mindful of your body’s response, and adjust your pace if you experience bloating, fatigue, or discomfort. Before attempting a prolonged fast, consult with your doctor if you have any pre-existing medical conditions or regularly take medication. Healthy Keto® is an excellent addition to any fasting regimen as it limits carbs while prioritizing non-genetically modified vegetables, grass-fed beef, full-fat organic dairy, eggs, and wild-caught fish. Let’s look at practical steps to prepare your body and ease into your first extended fast. Plan your refeed meal ahead of time — because after a long fast, you deserve a nutrient-packed glow-up meal, not a regretful binge. Watch the ElectrolytesIf you feel dizzy, weak, or like you might slap somebody…
Metabolism is a dynamic and intricate system, meticulously evolved over hundreds of millions of years from our bacterial ancestors for survival and reproduction. Intermittent fasting (IF) was a normal “feast and famine” type existence for animals and primitive man during our evolutionary histories. It evidently became a way of manipulating metabolism with known benefits of weight loss, increased stress resistance, suppression of inflammation, and numerous physiological changes at the cellular level. It remains an evolutionarily conserved adaptive response for the promotion of health of all animals including Homo sapiens. Also, during fasting body has an opportunity to release energy in the form of heat, which ultimately increases unimeal reviews complaints energy consumption and thus leads to the consumption of more calories. Scientific and medical studies also show that fasting can significantly change our state of health, especially regulating blood glucose.

Despite irritability, the participants of this study experienced a higher sense of achievement, pride, and self-control after the fasting period compared to the start of the study. Another 2019 study trying fasting for 4-21 days showed that hunger symptoms appeared in the early days of fasting, but the body adapts to the new situation after some days [5]. This condition is called insulin resistance, and it leads to higher blood sugar and fat storage.

